研究方向
上皮细胞生理病理学
学科方向
071003-生理学
0860-生物与医药
个人经历
2008.09-2012.06，2023白菜网址官网大全，逸仙班， 生物技术，理学学士
2012.09-2017.06，2023白菜网址官网大全，600全讯白菜官方网站，生理学，理学博士
2017.07-2023.05，2023白菜网址官网大全，600全讯白菜官方网站，特聘副研究员
2023.06-至今，2023白菜网址官网大全，600全讯白菜官方网站，副教授
讲授课程
本科生课程：《生理学实验》、《神经生物学实验》、《生物化学和细胞生物学讨论课》、《生理学和神经生物学讨论课》、《专业提升训练》
研究生课程：《上皮细胞生理学》
学术成就
上皮细胞定位于机体体表与内腔表层，在维持机体稳态平衡中发挥着重要的作用，其功能紊乱可导致多系统疾病的发生。张艺林博士以上皮细胞为研究对象，重点围绕上皮细胞的免疫调控、离子转运及细胞间对话等生理功能展开研究工作，以探究上皮细胞及其离子信号网络在人类健康与疾病中的关键调控作用机制，为靶向调节上皮细胞功能的疾病干预策略提供新的科学依据。
主要创新点
1）发现多种病原体感染可诱导气道上皮细胞内氯离子稳态失衡，推动生理性炎症向病理性炎症转化。在此过程中，首次发现一条全新的氯离子-SGK1信号通路，并系统性地阐述了该通路介导支气管扩张、新冠肺炎、肺弓形虫病等呼吸系统疾病炎症迁延不愈的病理新机制，以及靶向抑制该通路的抗炎治疗新策略。
2）揭示了慢性气道炎症性疾病发生时，气道上皮细胞释放的多种促炎细胞因子可作用于邻近的气道平滑肌细胞，诱导其过度收缩；验证了靶向调节信号下游的CaV1.2钙离子通道具有缓解模型小鼠气道高反应性的作用，提示该策略可作为哮喘等呼吸系统疾病潜在的治疗方案。
3）阐明了生殖道上皮细胞通过激活离子通道调节生殖道管腔离子微环境形成的机制，并揭示了这一特殊的离子微环境在宿主防御与生殖中的重要作用。
承担课题
1. 国家自然科学基金-青年项目，2019.01-2021.12
2. 广东省自然科学基金-面上项目，2025.01-2028.12
3. 广东省自然科学基金-博士启动项目，2018.05-2021.04
4. 广州市基础与应用基础研究项目，2022.04-2025.03
论文专著
1. Zhang YL#,*, Zhou YY, Ke LJ, Sheng J, Zou DY, Tang TT, Yang ZY, Chen L, Hou XC, Zhu J, Xu JB, Zhu YX, Zhou WL*. Lipopolysaccharide Triggers Luminal Acidification to Promote Defense Against Bacterial Infection in Vaginal Epithelium. Am J Pathol. 2024; 194(12): 2290-2301. [Featured article, IF = 4.7; 中科院2区]
2. Xu JB#, Guan WJ#,*, Zhang YL#, Qiu ZE, Chen L, Hou XC, Yue J, Zhou YY, Sheng J, Zhao L, Zhu YX, Sun J, Zhao J, Zhou WL*, Zhong NS*. SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl- concentration. Signal Transduct Target Ther. 2024; 9(1): 74. [IF = 40.8; 中科院1区Top]
3. Qiu ZE#, Chen L#, Hou XC#, Sheng J, Xu JB, Xu JW, Gao DD, Huang ZX, Lei TL, Huang ZY, Peng L, Yang HL, Lin QH, Zhu YX, Guan WJ, Lun ZR, Zhou WL*, Zhang YL*. Toxoplasma gondii infection triggers ongoing inflammation mediated by increased intracellular Cl− concentration in airway epithelium. J Infect. 2023; 86(1): 47-59. [IF = 14.3; 中科院1区Top]
4. Chen L#, Guan WJ#, Qiu ZE#, Xu JB#, Bai X, Hou XC, Sun J, Qu S, Huang ZX, Lei TL, Huang ZY, Zhao J, Zhu YX, Ye KN, Lun ZR, Zhou WL*, Zhong NS*, Zhang YL*. SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl− accumulation in respiratory epithelium. Signal Transduct Target Ther. 2022; 7(1): 255. [Cover Story，IF = 39.3; 中科院1区Top]
5. Huang ZX, Qiu ZE, Chen L, Hou XC, Zhu YX, Zhou WL*, Zhang YL*. Cellular mechanism underlying the facilitation of contractile response induced by IL-25 in mouse tracheal smooth muscle. Am J Physiol-Lung Cell Mol Physiol. 2022; 323(1): L27-L36. [Featured article, IF = 4.9; 中科院2区]
6. Qiu ZE, Xu JB, Chen L, Huang ZX, Lei TL, Huang ZY, Hou XC, Yang HL, Lin QH, Zhu YX, Zhao L*, Zhou WL*, Zhang YL*. Allicin facilitates airway surface liquid hydration by activation of CFTR. Front Pharmacol. 2022; 13: 890284. [IF = 6.1; 中科院2区Top]
7. Zhang YL#, Zhang RG#, Chen FY#, Qiu ZE, Chen L, Huang ZX, Huang J, Zhu YX, Zhao L*, Zhou WL*. Cellular Mechanism Underlying the Facilitation of Contractile Response Induced by Tumor Necrosis Factor-α in Mouse Tracheal Smooth Muscle. Am J Pathol. 2022; 192(1): 104-111. [IF = 5.1; 中科院2区Top]
8. Gao DD#, Lan CF#, Cao XN#, Chen L#, Lei TL, Peng L, Xu JW, Qiu ZE, Wang LL, Sun Q, Huang ZY, Zhu YX, Zhou WL*, Zhang YL*. G protein-coupled estrogen receptor promotes acrosome reaction via regulation of Ca2+ signaling in mouse sperm. Biol Reprod. 2022; 107(4): 1026-1034. [中科院2区]
9. Gao DD#, Huang JH#, Zhang YL#, Peng L, Deng WJ, Mai YN, Wu JR, Li PL, Ding N, Huang ZY, Zhu YX, Zhou WL*, Hu M*. Activation of TRPV4 stimulates transepithelial K+ secretion in rat epididymal epithelium. Mol Hum Reprod. 2022; 28(2): gaac001. [中科院小类2区]
10. Xu JB, Lu SJ, Ke LJ, Qiu ZE, Chen L, Zhang HL, Wang XY, Wei XF, He S, Zhu YX, Lun ZR, Zhou WL*, Zhang YL*. Trichomonas vaginalis infection impairs anion secretion in vaginal epithelium. PLoS Negl Trop Dis. 2021; 15(4): e0009319. [中科院小类1区Top]
11. Zhang YL*, Liu W, Xu JB, Sun Q, Qiu ZE, Chen L, Huang J, Zhu YX, Zhou WL*. Prostaglandin E2 stimulates anion and fluid secretion triggered by lipopolysaccharide in rat vaginal epithelium. Mol Cell Endocrinol. 2021; 526: 111219. [中科院大类2区]
12. Zhao L#, Liang YT#, Tian DB#, Zhang RG, Huang J, Zhu YX, Zhou WL*, Zhang YL*. Regulation of smooth muscle contractility by the epithelium in rat tracheas: role of prostaglandin E2 induced by the neurotransmitter acetylcholine. Ann Transl Med. 2021; 9(4): 313.
13. Gao DD#, Wang LL#, Xu JW, Qiu ZE, Zhu YX, Zhang YL*, Zhou WL*. Cellular mechanism underlying oxytocin-stimulated Cl− secretion in rat cauda epididymal epithelium. Am J Physiol-Cell Physiol. 2020; 319(4): C630-C640. [中科院2区]
14. Peng L#, Gao DD#, Xu JW, Xu JB, Ke LJ, Qiu ZE, Zhu YX, Zhang YL*, Zhou WL*. Cellular mechanisms underlying carbon monoxide stimulated anion secretion in rat epididymal epithelium. Nitric Oxide. 2020; 100-101: 30-37. [中科院大类2区]
15. Xu JB#, Zhang YL#, Huang J, Lu SJ, Sun Q, Chen PX, Jiang P, Qiu ZE, Jiang FN, Zhu YX, Lai DH, Zhong WD*, Lun ZR*, Zhou WL*. Increased intracellular Cl− concentration mediates Trichomonas vaginalis-induced inflammation in the human vaginal epithelium. Int J Parasitol. 2019; 49(9): 697-704. [中科院2区]
16. Xu JW#, Gao DD#, Peng L, Qiu ZE, Ke LJ, Zhu YX, Zhang YL*, Zhou WL*. The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium. Nitric Oxide. 2019; 90: 37-46. [中科院大类2区]
17. Zhang YL#*, Feng JC#, Ke LJ, Xu JW, Huang ZX, Huang J, Zhu YX, Zhou WL*. Mechanisms underlying the regulation of intracellular and luminal pH in vaginal epithelium. J Cell Physiol. 2019; 234(9): 15790-15799. [IF = 5.546; 中科院2区]
18. Gao DD#, Xu JW#, Qin WB#, Peng L, Qiu ZE, Wang LL, Lan CF, Cao XN, Xu JB, Zhu YX, Tang YG*, Zhang YL*, Zhou WL*. Cellular Mechanism Underlying Hydrogen Sulfide Mediated Epithelial K+ Secretion in Rat Epididymis. Front Physiol. 2019; 9: 1886. [中科院2区]
19. Shi R, Xu JW, Xiao ZT, Chen RF, Zhang YL, Lin JB, Cheng KL, Wei GY, Li PB, Zhou WL*, Su WW*. Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation. J Med Food. 2019; 22(9): 963-970.
20. Zhang YL#, Chen PX#, Guan WJ#, Guo HM#, Qiu ZE, Xu JW, Luo YL, Lan CF, Xu JB, Hao Y, Tan YX, Ye KN, Lun ZR, Zhao L, Zhu YX, Huang J, Ko WH, Zhong WD, Zhou WL*, Zhong NS*. Increased intracellular Cl− concentration promotes ongoing inflammation in airway epithelium. Mucosal Immunol. 2018; 11(4): 1149-1157. [IF = 7.352; 中科院大类1区Top]
21. 卢申姣#; 黄尔梦#; 黄洁虹; 朱蕴馨; 梁耀林; 梁国强; 张艺林; 周文良*. 神秘果对高脂模型小鼠的降血脂效应. 中药药理与临床. 2018; 34(02). [北大核心期刊]
22. Zhang YL, Xu JW, Wu XH, Chen PX, Wei F, Gao DD, Chen XW, Luo YL, Zhu YX, Huang J, Tan YX, Zhao L*, Zhou WL*. Relaxant Effect of Sodium Tanshinone IIA Sulphonate on Mouse Tracheal Smooth Muscle. Planta Med. 2017; 83(7): 624-630. [中科院小类2区]
23. Chen PX, Zhang YL, Xu JW, Yu MH, Huang JH, Zhao L*, Zhou WL*. Sodium tanshinone IIA sulfonate stimulated Cl−secretion in mouse trachea. PLoS One. 2017; 12(5): e0178226.
24. Yang DL#, Xu JW#, Zhu JG#, Zhang YL, Xu JB, Sun Q, Cao XN, Zuo WL, Xu RS, Huang JH, Jiang FN, Zhuo YJ, Xiao BQ, Liu YZ, Yuan DB, Sun ZL, He HC, Lun ZR, Zhong WD*, Zhou WL*. Role of GPR30 in estrogen-induced prostate epithelial apoptosis and benign prostatic hyperplasia. Biochem Biophys Res Commun. 2017; 487(3): 517-524.
25. Shi R, Xiao ZT, Zheng YJ, Zhang YL, Xu JW, Huang JH, Zhou WL*, Li PB, Su WW*. Naringenin Regulates CFTR Activation and Expression in Airway Epithelial Cells. Cell Physiol Biochem. 2017; 44(3): 1146-1160.
26. Guo HM, Gao JM, Luo YL, Wen YZ, Zhang YL, Hide G, Zhou WL*, Ayala FJ*, Lun ZR*. Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia. Proc Natl Acad Sci U S A. 2015; 112(14): 4435-40. [IF = 9.423; 中科院1区Top]
27. Huang J, Luo YL, Hao Y, Zhang YL, Chen PX, Xu JW, Chen MH, Luo YF, Zhong NS, Xu J, Zhou WL*. Cellular mechanism underlying hydrogen sulfide induced mouse tracheal smooth muscle relaxation: role of BKCa. Eur J Pharmacol. 2014; 741: 55-63.
28. Luo YL, Guo HM, Zhang YL, Chen PX, Zhu YX, Huang JH*, Zhou WL*. Cellular mechanism underlying formaldehyde-stimulated Cl− secretion in rat airway epithelium. PLoS One. 2013; 8(1): e54494.
授权发明专利
1. 周文良, 张艺林, 蒋平. TRPV4激动剂的新应用. 2022-08-12, 中国, CN202110267279.X.
