性别: 女
工作电话:020-84115532
职称: 副教授
学历: 理学博士
个人主页: http;//shimeigroupsysu.edu.cn/htmls/default zh.htm
电子邮件: zhuy68@mail.sysu.edu.cn
导师类型:博士生导师
学科方向:
071010-生物化学与分子生物学

 

研究方向

肿瘤发生发展的分子机制;
非编码RNA及短肽的功能;
肿瘤微环境代谢调控网络。

 

个人经历

教育经历：
2002/09-2006/06，2023白菜网址官网大全，600全讯白菜官方网站生物科学与技术系，生物科学专业，理学学士学位
2006/09-2011/06，2023白菜网址官网大全，600全讯白菜官方网站生物化学系，生物化学与分子生物学专业，理学博士学位

工作经历：
2011/09-2017/02，美国南加州大学，微生物分子学与免疫学系，研究助理（博士后）
2017/02至今，2023白菜网址官网大全，600全讯白菜官方网站，副教授

 

讲授课程

通识课《生活中的生物学》
专业选修课《肿瘤生物学》《细胞生物学II》
专业必修《大学生物》《大学生物实验》《细胞生物学实验》

 

学术成就

长期从事细胞信号传导及肿瘤生物学领域的研究，近年来主要研究非编码RNA和短肽的功能及其通过代谢重编程调控肿瘤进展。在国际杂志上发表论文22篇（影响因子5<IF<10，12篇；IF>10，9篇），总IF约265点，总他引超1000次，1篇论文被F1000推荐阅读，3篇论文为ESI前1%高被引；以第一、共一、共通讯或最后通讯作者在Hepatology、Nucleic Acids Res、Mol Ther等国际知名刊物发表论文11篇。作为第二完成人获2018年教育部自然科学一等奖；作为第四完成人获2018年广东省自然科学一等奖。
担任“Frontiers Cell and Developmental Biology”等杂志编委会成员和PLoS Pathogens等11本科学杂志审稿人。

 

承担课题

主持国家自然科学基金面上项目、青年项目，科技部国家重点研发计划子课题，广东省自然科学基金面上项目等。

 

论文专著

第一、共一及通讯作者论文：

  1. Xu T#, Zhu Y#, Xiong Y, Ge YY, Yun JP, Zhuang SM*. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells, Hepatology. 2009 Jul;50(1):113-21.（共一）
  2. Zhu Y#, Lu Y#, Zhang Q, Liu JJ, Li TJ, Yang JR, Zeng C, Zhuang SM*. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein, Nucleic Acids Res. 2012 May;40(10):4615-25. （共一）
  3. Lei X#, Zhu Y#, Jones T, Bai Z, Huang Y, Gao SJ*. A Kaposi's sarcoma-associated herpesvirus microRNA and its variants target the transforming growth factor β pathway to promote cell survival, J Virol. 2012 Nov;86(21):11698-711. （共一）
  4. Zhu Y#, Haecker I#, Yang Y, Gao SJ, Renne R*.  γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis, Curr Opin Virol.2013 Jun;3(3):266-75.（共一）
  5. Zhu Y, Huang YF, Jung JU, Lu C, Gao SJ*. Viral miRNA targeting of bicistronic and polycistronic transcripts. Curr Opin Virol. 2014 Aug; 7:66-72.
  6. Zhu Y, Ramos da Silva S, He M, Liang Q, Lu C, Feng P, Jung JU, Gao SJ*. An oncogenic virus promotes cell survival and cellular transformation by suppressing glycolysis. PLoS Pathog. 2016 May;12(5): e1005648. 
  7. Zhu Y, Li T, Ramos da Silva S, Lee JJ, Lu C, Eoh H, Jung JU, Gao SJ*. A critical role of glutamine and asparagine γ-nitrogen in nucleotide biosynthesis in cancer cells hijacked by an oncogenic virus. MBio. 2017 Aug 15;8(4). pii: e01179-17.
  8. Wang YL#, Liu JY#, Yang JE#, Yu XM, Chen ZL, Chen YJ, Kuang M, Zhu Y*, Zhuang SM*. Lnc-UCID promotes G1/S transition and hepatoma growth by preventing DHX9-mediated CDK6 downregulation. Hepatology. 2019 Jul;70(1):259-275.（共通）
  9. Lin YF, Xiao MH, Chen HX, Meng Y, Zhao N, Yang L, Tang H, Wang JL, Liu X, Zhu Y*, Zhuang SM*. A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death Dis. 2019 Jul 11;10(7):528.（共通）
  10. Xiao MH#, Lin YF#, Xie PP#, Chen HX, Deng JW, Zhao N, Xie C, Meng Y, Liu X, Zhuang SM*, Zhu Y*, Fang JH*. Downregulation of a mitochondrial micropeptide, MPM, promotes hepatoma metastasis by enhancing mitochondrial complex I activity. Mol Ther. 2022 Feb 2;30(2):714-725.（共通）
  11. Sang Y, Liu JY, Wang FY, Luo XY, Chen ZQ, Zhuang SM*, Zhu Y*. Mitochondrial micropeptide STMP1 promotes G1/S transition by enhancing mitochondrial complex IV activity. Mol Ther. 2022 Aug 3;30(8):2844-2855.（共通）

合作者论文：

  1. Xu T, Zhu Y, Wei QK, Yuan Y, Zhou F, Ge YY, Yang JR, Su H, Zhuang SM*. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma, Carcinogenesis. 2008 Nov;29(11):2126-31.
  2. Moody R, Zhu Y, Huang Y, Cui X, Jones T, Bedolla R, Lei X, Bai Z, Gao SJ*. KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways, PLoS Pathog. 2013 Dec;9(12):e1003857.
  3. Bai Z, Huang Y, Li W, Zhu Y, Jung JU, Lu C, Gao SJ*. Genomewide mapping and screening of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) 3' untranslated regions identify bicistronic and polycistronic viral transcripts as frequent targets of KSHV microRNAs, J Virol. 2014 Jan;88(1):377-92.
  4. Zhao N, Wang R, Zhou L, Zhu Y, Gong J, Zhuang SM*. MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3. Mol Cancer. 2014 Feb 24;13:35.
  5. Lee MS, Yuan H, Jeon H, Zhu Y, Yoo S, Shi S, Krueger B, Renne R, Lu C, Jung JU, Gao SJ*. Human mesenchymal stem cells of diverse origins support persistent infection with Kaposi’s Sarcoma-Associated Herpesvirus and manifest distinct angiogenic, invasive, and transforming phenotypes. MBio. 2016 Jan 26;7(1):e02109-15.
  6. Li W, Yan Q, Ding X, Shen C, Hu M, Zhu Y, Qin D, Lu H, Krueger BJ, Renne R, Gao SJ, Lu C*. The SH3BGR/STAT3 pathway regulates cell migration and angiogenesis induced by a gammaherpesvirus microRNA. PLoS Pathog. 2016 Apr 29;12(4):e1005605.
  7. Li T, Zhu Y, Cheng F, Lu C, Jung JU, Gao SJ*. Oncogenic Kaposi's Sarcoma-Associated Herpesvirus upregulates argininosuccinate synthase 1, a rate-limiting enzyme of the citrulline-nitric oxide cycle, to activate the STAT3 pathway and promote growth transformation. J Virol. 2019 Feb 5;93(4). pii: e01599-18.
  8. Xie C, Zhang LZ, Chen ZL, Zhong WJ, Fang JH, Zhu Y, Xiao MH, Guo ZW, Zhao N, He X, Zhuang SM*. A novel hMTR4-PDIA3P1-miR-125/124-TRAF6 regulatory axis and its function in NF-κB signaling and chemoresistance. Hepatology. 2020 May;71(5):1660-1677.
  9. Li SY, Zhu Y, Li RN, Huang JH, You K, Yuan YF*, Zhuang SM*. LncRNA lnc-APUE is repressed by HNF4α and promotes G1/S phase transition and tumor growth by regulating miR-20b/E2F1 axis. Adv Sci. 2021 Feb 1;8(7):2003094.
  10. Xie C, Li SY, Fang JH, Zhu Y, Yang JE*. Functional long non-coding RNAs in hepatocellular carcinoma. Cancer Lett. 2021 Mar 1;500:281-291.
  11. Xie C#, Wang FY#, Sang Y, Chen B, Huang JH, He FJ, Li H, Zhu Y, Liu X, Zhuang SM*, Fang JH*. Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis. Cancer Res. 2022 Jul 5;82(13):2431-2443.